Progress toward the total synthesis of saudin: development of a tandem Stille-oxa-electrocyclization reaction.
نویسندگان
چکیده
[reaction: see text] A diastereoselective tandem Stille-oxa-electrocyclization reaction provides access to the core of the diterpenoid natural product saudin. Additionally, this new reaction sequence was extended to the convergent preparation of related polycyclic pyran systems.
منابع مشابه
Convergent and diastereoselective synthesis of the polycyclic pyran core of saudin.
The natural product saudin was found to induce hypoglycemia in mice and, therefore, could be an appealing lead structure for the development of new agents to treat diabetes. A diastereoselective tandem Stille-oxa-electrocyclization reaction has been developed which provides access to the core structure of saudin in a rapid and convergent manner. This new reaction has been extended to the conver...
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ورودعنوان ژورنال:
- Organic letters
دوره 7 12 شماره
صفحات -
تاریخ انتشار 2005